Cannabidiol is usually abbreviated as CBD, it is a phytocannabinoid that was discovered in 1940 and was first thought to be psychoactive (it was later discovered as non-psychoactive. It is one of over 113 cannabinoids found in hemp plants, representing almost 40% of the plant’s extract, the closest to it is Tetrahydrocannabinol (THC).
The first thing you think when you see CBD is that it is an acronym but let me shock you by letting you know that it is not an acronym. CBD stands for Cannabidiol.
There are lots of exciting facts on CBD than just its many health benefits, we will be looking at a few of these facts and some misconceptions that people have concerning CBD. The following are some of the facts, quips, and common misconceptions about CBD;
Cannabidiol is one of the many compounds that is found in cannabis, it belongs to a category of molecules called cannabinoids. Out of all the compounds, CBD and THC (Tetrahydrocannabinol) are the compounds having the highest concentrations.
CBD is basically non-psychoactive.It has been tested on mice at Virginia Commonwealth University and it was found to have no psychoactive effects and reduced inflammatory and neuropathic pain.A psychoactive substance or drug is one that has the tendency of changing brain function which results in alteration in mood, perception, behavior, cognition, and consciousness. CBD does not alter mood or change the brain function in anyway. Unlike THC, CBD can be consumed at an appreciable dose without having any form of side effect. THC is psychoactive and should not be consumed in high doses.
Cannabidiol can be taken into the body through more than one way, it could be through inhaling cannabis vapor or smoke, cooked into edibles, by mouth or as an aerosol spray into the cheek. It may be supplied as a full-plant based CBD-dominant hemp extract, or as CBD oil containing only CBD as the active ingredient without terpenes or THC.
Just like any other substances around, CBD also has some downsides especially if abused and taking without proper prescription from a medical expert. Some of the side effects that come with CBD include decreased appetite, malaise, sleeping problem, diarrhea, somnolence, and fatigue among others.
It must be noted here that cannabidiol (CBD) will never get you high, only cannabis has the potential of getting you high. Unlike THC, CBD does not have intoxicating effects, this is because CBD does not bind to the nerve receptors in the brain and as such it causes its therapeutic action through other indirect means. It has been discovered that it reacts with a number of different biological targets like neurotransmitter receptors and cannabinoid receptors. The mechanism of action of CBD in terms of its therapeutic and psychoactive effects has not been fully established.
Both the marijuana-derived and hemp-derived form of CBD are from cannabis plant, both the marijuana and hemp serve different functions and as such they involve difference legalities. You will usually see CBD being advertised in two forms; marijuana-derived and hemp-derived. Hemp-based CBD is legal and can be found in health food and just recently it has been removed from the list of prohibited or banned substances by the World Anti-Doping Agency, which means it can now be used in sports. On the other hand, marijuana-based CBD contains THC while hemp-based CBD does not contain CBD.
CBD products are extracted from either industrial hemp plants or medical cannabis. Although, it is illegal under federal law, it has been legalized in majority of the states. Hence, its consumers can use CBD as a natural supplement without worrying about any legal implications.
The use of CBD as a medication is fast gaining ground, it is one of the substances whose health benefits are far reaching across several ailments. It can be used as a pain reliever, it can help to tackle insomnia, bowel diseases, arthritis, acne, epilepsy, and it can also be used to combat several neurological disorders.
For example, in the United States, CBD drug Epidiolex has been certified and approved by the Food and Drug Administration for treating two different epilepsy disorders. Epidiolex is a drug produced by GW Pharmaceuticals in the United Kingdom, it contains 98% CBD without any THC and it has been used as trials on children with epilepsy.
Cannabidiol has been found to have several promising potential therapy for lots of ailments that medical professionals have experienced difficulty in treating. It helps to treat chronic, neuropathic, and cancer-related pains, epilepsy, Parkinson’s, Inflammation, Dyskinesia, Broken bones, Acne, Depression, Nausea, Anxiety, Schizophrenia, Heart diseases, Multiple Sclerosis, and Irritable Bowel Syndrome (IBS) among others.
Cannabidiol is an allosteric modulator at several receptor sites in the human body. Allosteric modulators help to change the shape of specific receptors in order to alter the ability to interact with neurotransmitters. CBD is a positive allosteric modulator enhances the abilities of mu and delta opioid receptors to receive endogenous enkephalins which can help to naturally reduce pain and increase of life.
CBD on the other hand, is a negative allosteric modulator of the CB1 receptor in order to reduce its ability to bind with THC. It antagonizes GPR55 receptors, GPR55 is a receptor in the brain that helps to control blood pressure and bone density.
CBD also activates both TRPV1 and PPAR-gamma receptors. TRPV1 receptors are responsible for regulating temperature, inflammation, and pain while PPAR-gamma receptors are found in the cell’s nuclei; they play vital role in insulin sensitivity, lipid uptake, and the degradation of beta-amyloid plaque.
High CBD strains may be vital in improving mental disorders because of its ability to relief PTSD, anxiety, and depression. Most of the researches in this regard are still in the pre-trial stages or the clinical studies are just being concluded with experimental animals. However, CBD has shown great promises of being able to combat mental illnesses.
CECD is a condition where an individual has a lower amount of endogenous cannabinoids than is necessary to promote health and well-being. CECD is believed to be responsible or play significant role in ailment such as Huntington’s, Parkinson’s, Motion sickness, Migraines, fibromyalgia, Autism, and Post-Traumatic Stress Disorder (PTSD) among others. Majority of the medications used for treating these ailments come with several side effects while CBD can be used to treat these ailments by increasing endocannabinoids in the body without any risks as we have with using pharmaceuticals.
Endocannabinoids are cannabinoids produced naturally in the human body while cannabinoids are phytocannabinoids gotten from plants. Anandamide is an example of endocannabinoid that is responsible for activating CB1 receptors. CBD oil helps to inhibit anandamide to ensure it is readily available to the CB1 receptors. Activating CB1 receptor helps to relieve depression, lower intestinal inflammation, increase myelin formation, lower blood pressure, lower prolactin, reduce fear and anxiety among others.
It is interesting to note how CBD and THC work when they are combined. They both have a way of complementing each other as they both have diverse functions and the constituents that make each one of them differs. For example, if you use a strain of CBD and THC in same ratio to combat anxiety, the CBD will help to counteract the feelings of paranoia that the THC is capable of inducing. There are still further researches ongoing to understand how different ratios of CBD and THC work.
With the many health benefits that CBD offers you can take CBD alongside your other supplements such as omegas, vitamin D, and Probiotics. Some medical experts recommend taking 5mg of CBD in the morning to kick start your day and if you want to use it to get a good sleep, you can take 15mg, while you can take as much as 15-35 mg for muscle aches and pains.
The Body Absorbs more Nutrients When You Ingest CBD than When it is Inhaled. Eating the milligram of CBD allows your body to absorb up to 70 -90% of the plant’s potent nutrients compared to when it is inhaled.
Some people think ingesting CBD causes any kind of physical reaction. This is not true, as long as the CBD you ingest does not contain THC. Before you can experience any negative physical side effects, you must have ingested an amount equivalent to 20mg per each kilogram of your body weight.
CBD will help you to reduce the effects of puffy eye. Rashes, psoriasis, and you can also apply it on part of the skin where you have sunburn.
A study carried out in the University of Aberdeen, Scotland showed that the molecular structure of CBD has contributed to the development of synthesized positive allosteric modulator that can be used to treat neurological disorders and pains.
Some people have the notion that CBD is sedating, this is actually not true. CBD is not sedating, in fact, it has been found to counteract the sedative effects of THC. Even high doses of CBD as much as 600mg in a single dose did not cause any sedative effect. One of the myth about CBD is that “a little CBD is enough” but this is incorrect, you can take it as long as it does not contain THC, there will be no problem.
CBD can serve as a major motivator for you, experiments carried out on mice showed that it acted as a stainable and significant antidepressant. Its effect was similar to that of Tofranil, a popular medication for depression.
Laboratory research has shown that cannabidiol reduces THC clearance, increases plasma concentrations which is capable of raising THC availability to receptors and thus enhances its effect in a dose dependent manner.
In vitro, it was discovered that cannabidiol inhibited receptors that affect the activity of voltage-dependent potassium and sodium channels, which may have significant effects on neural activity.
It must be noted that once the many researches being carried out on the certainty of some of the many benefits of CBD are completed and it is confirmed to be capable of having same effect as it had on animals in humans, then it’s usage will be far reaching. Once this is confirmed, the next will be to know how to administer the doses in right proportions. It has been predicted that the cannabis market will grow by 700 percent by 2020.
When this happens its benefits will cut across several spheres as it will be a major avenue through which employment will be created and thus its impact on the economy will be massive.